The cees dekker Diaries
The cees dekker Diaries
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Nanofabrication of electrodes with sub-five nm spacing for transportation experiments on single molecules and metallic clusters
2010, developed a fresh way (‘wedging transfer’) to control nanostructures; 1st report of DNA translocation as a result of graphene nanopores; and understood hybrid nanopores by directed insertion of α-hemolysin into solid-state nanopores
Our investigation ranges through the biophysics of DNA to artificial cells and over and above. Remember to have a look beneath in the spectrum of our present tasks.
‘At the outset we checked out biological programs which has a Bodily watch and acted on The premise from the equipment we realized. It took a number of years prior to we commenced Doing the job much more on the large Organic difficulties. I then began to contact it nanobiology, a phrase that did not exist at enough time.
2011, initially in vitro measurements of transportation across just one biomimetic nuclear pore sophisticated; improvement of multiplexed magnetic tweezers for kilo-molecule experiments; and resolved the system of homology recognition in DNA homologous recombination
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Quite cool, but that wasn’t actually wherever my interest lay. I wished to pioneer And that i experienced the sensation that was not doable, as the most intriguing elementary insights experienced already been uncovered. But my area had formulated lots of thrilling new equipment to evaluate unique molecules. I decided that I desired to implement this to ceesdekker.net biology, to take a look at it from the physical point of view.’
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2008, very first observation of protein-coated DNA translocation by means of nanopores; settled the origin in the electrophoretic force on DNA in nanopores; discovered a significant velocity increase of microtubules in electric powered fields; found out an anomalous electro-hydrodynamic orientation of microtubules; and solved the origin of sound in carbon nanotubes in liquid
2004, discovery of latest physics in translocation of DNA via nanopores; to start with experimental review of ions conduction in nanofluidic channels; initial electrochemistry with unique solitary-wall carbon nanotubes; STM detection and Charge of phonons in carbon nanotubes; 1st electrical docking of microtubules on kinesin-coated nanostructures; initial biophysics characterization with the mechanical Qualities of double-stranded RNA; and first solitary-molecule study of DNA translocation by a restriction-modification enzyme.